Creatine monohydrate (CrM) is one of the most widely used nutritional supplements among active individuals and athletes to improve high-intensity exercise performance and training …
A Popov, N Brazhe, K Morozova, K Yashin… - Nature …, 2023 - nature.com
How aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older …
Background and Aims: We evaluated adipose tissue-derived hormones, body composition, serum metabolic profile, levels of brain-derived neurotrophic factor (BDNF), and the …
QQ Wang, G Yin, JR Huang, SJ Xi, F Qian, RX Lee… - Cells, 2021 - mdpi.com
Population aging is occurring rapidly worldwide, challenging the global economy and healthcare services. Brain aging is a significant contributor to various age-related …
Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial dysfunction, reduced NAD+/NADH (redox) ratio, and postmitotic senescence. Sirtuins are …
X Long, K He, M Zhang, M Li, Z Wang, C Wang… - … and Physiology Part C …, 2023 - Elsevier
Ammonia is one of the most serious environmental stressors which severely affect fishery production. Ammonia toxicity to fish has a tight relationship with oxidative stress …
In inborn errors of metabolism, such as amino acid breakdown disorders, loss of function mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of …
T McMorris, BJ Hale, BS Pine, TB Williams - Behavioural Brain Research, 2024 - Elsevier
Creatine supplementation has been put forward as a possible aid to cognition, particularly for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However …
Z Ren, L Zhao, M Zhao, T Bao, T Chen, A Zhao… - Cell Reports …, 2024 - cell.com
Cognitive impairment in the elderly is associated with alterations in bile acid (BA) metabolism. In this study, we observe elevated levels of serum conjugated primary bile acids …