Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Increasing knowledge of intertumor heterogeneity, intratumor heterogeneity, and cancer
evolution has improved the understanding of anticancer treatment resistance. A better …

Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

Background While mathematical models are often used to predict progression of cancer and
treatment outcomes, there is still uncertainty over how to best model tumor growth. Seven …

Background The precise characterization of individual tumors and immune
microenvironments using transcriptome sequencing has provided a great opportunity for …

Cancer is a set of complex pathologies that has been recognized as a major public health
problem worldwide for decades. A myriad of therapeutic strategies is indeed available …

Highlights•Cancer is a heterogeneous and evolving disease, yet most drugs are
administered to simply give the maximum dose.•Treatment scheduling currently ignores the …

Precision medicine requires accurate technologies for drug administration and proper
systems pharmacology approaches for patient data analysis. Here, plasma …

Abstract Systems biology is today such a widespread discipline that it becomes difficult to
propose a clear definition of what it really is. For some, it remains restricted to the genomic …

Over the last decade, metronomic chemotherapy has been increasingly considered as an
attractive strategy for treating cancer in a variety of settings. Beside pharmaco-economic …