The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium,
leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …