Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

The blood-brain barrier (BBB) separates the central nervous system (CNS) from the
peripheral tissues. However, this does not prevent hormones from entering the brain, but …

The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …

Rationale and objectives Fear conditioning is an important aspect in the pathophysiology of
anxiety disorders. The fear-potentiated startle test is based on classical fear conditioning …

Preliminary evidence suggests that the neuropeptide, neurotensin (NT) may regulate
fear/anxiety circuits. We investigated the effects of PD149163, a NT1 receptor agonist, on …

Recent research points to the connection between behavioral and gut disorders. Early
adverse events are associated with inflammatory bowel disease (IBD). In animal models …

Secretin holds a unique place in the history of endocrinology and gastrointestinal
physiology, as it is the first peptide designated as a hormone. During the last century since …

Iv injection of secretin activates neurons in brain areas controlling autonomic function and
emotion. Peripheral administration of secretin inhibits gastric functions through a central …

In the present study expression levels of secretin and secretin receptor mRNAs in several
brain regions of rats ranging in age from postnatal days 7 to 60 were investigated by …

The discovery of secretin initiated the field of endocrinology. Over the past century, multiple
gastrointestinal functions of secretin have been extensively studied, and it was discovered …