Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Atherosclerosis is one of the key problems of modern medicine, which is due to the high
prevalence of atherosclerotic cardiovascular diseases and their significant share in the …

Cardiovascular disease is a major cause of mortality and morbidity. Current research
investigating the roles of nitric oxide (NO) with relevance to the cardiovascular system is an …

Arginase metabolizes the semi-essential amino acid l-arginine to l-ornithine and urea. There
are two distinct isoforms of arginase, arginase I and II, which are encoded by separate …

Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a
high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture …

Aims Extrahepatic arginases are postulated to be involved in cardiovascular-related
pathologies by competing with nitric oxide synthase (NOS) for the common substrate l …

Our purpose is to simulate the airflow inside the healthy Chinese nose with normal nasal
structure and function by computational fluid dynamics (CFD) method and to analyze the …

Objective: Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnoea,
is associated with impaired vascular function despite unaltered response to nitric oxide …

Arginase is a metalloenzyme which hydrolyzes L‐arginine to L‐ornithine and urea. Since its
discovery, in the early 1900s, this enzyme has gained increasing attention, as literature …