Galanthamine from snowdrop—the development of a modern drug against Alzheimer's disease from local Caucasian knowledge

M Heinrich, HL Teoh - Journal of ethnopharmacology, 2004 - Elsevier
In recent years, galanthamine isolated from several members of the Amaryllidaceae
(Leucojum spp., Narcissus species, Galanthus spp.) has become an important therapeutic …

Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia

PL Le Bars, MM Katz, N Berman, TM Itil, AM Freedman… - Jama, 1997 - jamanetwork.com
Context.—EGb 761 is a particular extract of Ginkgo biloba used in Europe to alleviate
symptoms associated with numerous cognitive disorders. Its use in dementias is based on …

Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trialCommentary: Another piece of the Alzheimer's jigsaw

M Rösler, T Bayer, R Anand, A Cicin-Sain, S Gauthier… - Bmj, 1999 - bmj.com
Objectives: To assess the effects of rivastigmine on the core domains of Alzheimer9s
disease. Design: Prospective, randomised, multicentre, double blind, placebo controlled …

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

NC Bodick, WW Offen, AI Levey, NR Cutler… - Archives of …, 1997 - jamanetwork.com
Objective: To evaluate the therapeutic effects of selective cholinergic replacement with
xanomeline tartrate, an ml and m4 selective muscarinic receptor (mAChR) agonist in …

Practice parameter: Management of dementia (an evidence-based review)[RETIRED] Report of the Quality Standards Subcommittee of the American Academy of …

RS Doody, JC Stevens, C Beck, RM Dubinsky… - Neurology, 2001 - AAN Enterprises
Objective: To define and investigate key issues in the management of dementia and to make
literature-based treatment recommendations. Methods: The authors searched the literature …

Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study

SL Rogers, RS Doody, RC Mohs… - Archives of internal …, 1998 - jamanetwork.com
Background Donepezil hydrochloride (Aricept) is a selective acetylcholinesterase inhibitor
developed for the treatment of Alzheimer disease. This phase 3 study was 1 of 2 pivotal trials …

Commonly used herbal medicines in the United States: a review

S Bent, R Ko - The American journal of medicine, 2004 - Elsevier
Herbal medicines are widely used in the United States, with approximately one quarter of
adults reporting use of an herb to treat a medical illness within the past year. Herbs contain …

Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities

JL Cummings, HV Vinters, GM Cole, ZS Khachaturian - Neurology, 1998 - AAN Enterprises
Alzheimer's disease (AD) can be diagnosed with a considerable degree of accuracy. In
some centers, clinical diagnosis predicts the autopsy diagnosis with 90% certainty in series …

[HTML][HTML] Acetylcholinesterase inhibitors in Alzheimer's disease

BM McGleenon, KB Dynan… - British journal of clinical …, 1999 - ncbi.nlm.nih.gov
Introduction compromised in AD [2] and the resultant cholinergic deficit contributes to the
cognitive impairment of these Alzheimer's Disease (AD) is the most common single cause of …