Linopirdine (3, 3-bis (4-pyridinylmethyl)-1-phenylindolin-2-one, DUP996) is an extensively
studied representative of a class of cognition enhancing compounds that increase the …

There is great interest in the ethical issues associated with Alzheimer's disease (AD) and
related dementias given the prevalence of AD and the evolving neuroscience landscape in …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

Objective: To compare rates of cognitive decline between probable Alzheimer's disease
(AD) patients treated with long-duration cholinesterase inhibitors (ChE-Is) and those who …

The aim of the investigation was to prepare and characterize microemulsion/mucoadhesive
microemulsion of tacrine (TME/TMME), assess its pharmacokinetic and pharmacodynamic …

Variation in drug efficacy and toxicity remains an important clinical concern. Presently, single
nucleotide polymorphisms (SNPs) only explain a portion of this problem, even in situations …

ABSTRACT The Clock Drawing Test (CDT) is a simple neuropsychological screening
instrument that is well accepted by patients and has solid psychometric properties. Several …

Two doses of idebenone were studied in a prospective, randomized, double-blind, placebo-
controlled multicentre study in patients suffering from dementia of the Alzheimer type (DAT) …

Synopsis Tacrine is a centrally acting cholinesterase inhibitor with additional
pharmacological activity on monoamine levels and ion channels. It has been postulated that …

The third edition of this successful textbook has been completely updated throughout and
includes new chapters on electrophysiological tests, biological markers, global staging …