Cannabis is the most commonly used substance of abuse in the United States after alcohol
and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a …

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information
from numerous cortical and subcortical areas and converges updated information to output …

Objective This review of the scientific literature examines the potential adult sequelae of
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …

Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

During adolescence, both rodent and human studies have revealed dynamic changes in the
developmental trajectories of corticolimbic structures, which are known to contribute to the …

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …

Adolescence is a period of dramatic neural reorganization creating a period of vulnerability
and the possibility for the development of psychopathology. The maturation of various neural …

Neuronal circuits within the prefrontal cortex (PFC) mediate higher cognitive functions and
emotional regulation that are disrupted in psychiatric disorders. The PFC undergoes …

There has been a shift surrounding societal and legal perspectives on cannabis reflecting
changing public attitudes towards the perceived safety and social acceptability of cannabis …

Marijuana use during adolescence has reached virtually every strata of society. The general
population has the perception that marijuana use is safe for mature people and therefore is …