[HTML][HTML] Lipedema—pathogenesis, diagnosis, and treatment options

P Kruppa, I Georgiou, N Biermann, L Prantl… - Deutsches Ärzteblatt …, 2020 - ncbi.nlm.nih.gov
Background Lipedema is often unrecognized or misdiagnosed; despite an estimated
prevalence of 10% in the overall female population, its cause is still unknown. There is …

Cause and management of lipedema‐associated pain

H Aksoy, AS Karadag, U Wollina - Dermatologic therapy, 2021 - Wiley Online Library
Lipedema is a painful, underdiagnosed adipose tissue disorder, characterized by
symmetrical swelling of the extremities due to subcutaneous fat deposition in the buttocks …

Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?

PAN Nankam, M Cornely, N Klöting… - Frontiers in …, 2022 - frontiersin.org
Lipedema may be considered a model for healthy expandability of subcutaneous adipose
tissue (SAT). This condition is characterized by the disproportional and symmetrical SAT …

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema

M Ishaq, N Bandara, S Morgan, C Nowell… - International Journal of …, 2022 - nature.com
Objectives Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is
often mistaken for obesity and causes significant impairment to mobility and quality-of-life …

Lipedema: insights into morphology, pathophysiology, and challenges

A Poojari, K Dev, A Rabiee - Biomedicines, 2022 - mdpi.com
Lipedema is an adipofascial disorder that almost exclusively affects women. Lipedema
leads to chronic pain, swelling, and other discomforts due to the bilateral and asymmetrical …

A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema

S Wolf, JH Rannikko, R Virtakoivu, P Cinelli… - Frontiers in …, 2022 - frontiersin.org
Lipedema is a chronic and progressive adipose tissue disorder, characterized by the painful
and disproportionate increase of the subcutaneous fat in the lower and/or upper extremities …

Lipedema research—quo vadis?

AM Ernst, H Bauer, HC Bauer, M Steiner… - Journal of Personalized …, 2022 - mdpi.com
When studying the current literature, one might get the impression that lipedema is a
“modern” disease, with increasing incidence and augmenting prevalence throughout …

3D spheroids derived from human lipedema ASCs demonstrated similar adipogenic differentiation potential and ECM remodeling to non-lipedema ASCs in vitro

S Al-Ghadban, IA Pursell, ZT Diaz, KL Herbst… - International journal of …, 2020 - mdpi.com
The growth and differentiation of adipose tissue-derived stem cells (ASCs) is stimulated and
regulated by the adipose tissue (AT) microenvironment. In lipedema, both inflammation and …

Multi-level analysis of adipose tissue reveals the relevance of perivascular subpopulations and an increased endothelial permeability in early-stage lipedema

K Strohmeier, M Hofmann, J Jacak, MS Narzt… - Biomedicines, 2022 - mdpi.com
Lipedema is a chronic, progressive disease of adipose tissue with unknown etiology. Based
on the relevance of the stromal vascular fraction (SVF) cell population in lipedema, we …

[PDF][PDF] Update in the management of lipedema

I Forner-Cordero, A Forner-Cordero… - International …, 2021 - academia.edu
Introduction: Lipedema is a chronic feminine disease that causes abnormal fat deposition in
lower limbs and occasionally upper limbs. Easy bruising and pain are common. Lipedema …