Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer's disease
V Lau, L Ramer, MÈ Tremblay - Nature Communications, 2023 - nature.com
Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
A reduced removal of dysfunctional mitochondria is common to aging and age-related
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
Synaptic oligomeric tau in Alzheimer's disease—A potential culprit in the spread of tau pathology through the brain
In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …
LRP1 is a master regulator of tau uptake and spread
The spread of protein aggregates during disease progression is a common theme
underlying many neurodegenerative diseases. The microtubule-associated protein tau has …
underlying many neurodegenerative diseases. The microtubule-associated protein tau has …
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
B Caballero, M Bourdenx, E Luengo, A Diaz… - Nature …, 2021 - nature.com
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
Mechanisms of pathogenic tau and Aβ protein spreading in Alzheimer's disease
P d 'Errico, M Meyer-Luehmann - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is pathologically defined by extracellular accumulation of amyloid-
β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of …
β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of …
Bassoon contributes to tau-seed propagation and neurotoxicity
Tau aggregation is a defining histopathological feature of Alzheimer's disease and other
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …
Curcumin's nanomedicine formulations for therapeutic application in neurological diseases
The brain is the body's control center, so when a disease affects it, the outcomes are
devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases …
devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases …
Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease
Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …