Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Purpose Radiation-induced fibrosis (RIF) is a long-term side effect of external beam
radiation therapy for the treatment of cancer. It results in a multitude of symptoms that …

Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and
severe late effect of thoracic radiation therapy. The goal of this study was to determine …

Although radiation therapy provides the backbone of primary and adjuvant therapy for
several thoracic malignancies, the lungs have long been known to be exquisitely sensitive to …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …

Radiation-induced lung fibrosis (RILF) is a severe side effect of radiotherapy in lung cancer
patients that presents as a progressive pulmonary injury combined with chronic …

Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation in clinic
with poor prognosis and limited therapeutic options. Previous results have shown that …

Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce
pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor …

Introduction: There is a limited array of currently available medicinals that are useful for
either the prevention, mitigation or treatment of bodily injuries arising from ionizing radiation …