Background Twin studies have provided evidence that both genetic and environmental
factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples …

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …

With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …

Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the …

Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …

Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …

Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …