Background The advent of immune checkpoint inhibitors (ICIs) has revolutionized the
therapeutic options of hepatobiliary malignancies. However, the clinical benefit provided by …

Cholangiocarcinoma (CCA) is a group of malignant heterogeneous cancer arising from the
biliary tree. CCA has become a global health problem with rising incidence and mortality …

Six Gasdermins (GSDM) family members participate in various biological processes
especially pyroptosis, as well as in the initiation and development of many types of cancer …

Pyroptosis is a type of programmed cell death (PCD) accompanied by an inflammatory
reaction and the rupture of a membrane. Pyroptosis is divided into a canonical pathway …

Background The high postoperative recurrence rate and refractoriness of relapsed tumors
are still a conundrum for the clinical management of osteosarcoma (OS). New therapeutic …

The advent of immunotherapy, which improves the immune system's ability to attack and
eliminate tumors, has brought new hope for tumor treatment. However, immunotherapy …

Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality but lacks
effective treatments thus far. Although the emergence of immune checkpoint inhibitors in …

Simple Summary Immune checkpoint inhibitors (ICIs) are being increasingly used after
primary treatment of early-stage tumors to treat any residual disease and prevent …

Background Most intrahepatic cholangiocarcinomas (ICCs) are diagnosed at advanced
stage with an extremely poor prognosis. For these patients, combining targeted therapies …

Objective To investigate whether pre-treatment contrast-enhanced MRI could predict the
therapeutic response of systemic treatment in advanced intrahepatic cholangiocarcinoma …