Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin,
there has been an increasing interest in the study of undifferentiated progenitors that have …

Desirable cells for human cell therapy would be ones that can be generated by simple
isolation and culture techniques using a donor sample obtained by non-invasive methods …

The development of a biotechnological platform for the removal of waste products (eg
uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current …

Renal cells are used in basic research, disease models, tissue engineering, drug screening,
and in vitro toxicology. In order to provide a reliable source of human renal cells, we …

For patients with severe kidney or liver failure the best solution is currently organ
transplantation. However, not all patients are eligible for transplantation and due to limited …

The limited removal of metabolic waste products in dialyzed kidney patients leads to high
morbidity and mortality. One powerful solution for a more complete removal of those …

In patients with chronic kidney disease (CKD), adequate renal clearance is compromised,
resulting in the accumulation of a plethora of uremic solutes. These uremic retention solutes …

Bioartificial kidneys (BAKs) containing human primary renal proximal tubule cells (HPTCs)
have been applied in clinical trials. The results were encouraging, but also showed that …

Recent advances in developmental biology and stem cell technology have led to the
engineering of functional organs in a dish. However, the limited size of these organoids and …

With the world-wide increase of patients with renal failure, the development of functional
renal replacement therapies have gained significant interest and novel technologies are …