Human tissue kallikreins: physiologic roles and applications in cancer

CA Borgono, IP Michael, EP Diamandis - Molecular cancer research, 2004 - AACR
Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases
and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are …

A three-lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma

W Cao, J Liu, Z Liu, X Wang, ZG Han, T Ji, W Chen… - Oral oncology, 2017 - Elsevier
Abstract Objective Long non-coding RNAs (lncRNAs) have important biological functions
and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic …

Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR) combining anti-EGFR antibody with tyrosine kinase inhibitor

S Huang, EA Armstrong, S Benavente, P Chinnaiyan… - Cancer research, 2004 - AACR
Molecular inhibition of epidermal growth factor receptor (EGFR/HER1) signaling is under
active investigation as a promising cancer treatment strategy. We examined the potency of …

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

JJ Higgins, J Pucilowska, RQ Lombardi, JP Rooney - Neurology, 2004 - AAN Enterprises
Background: Identifying the genetic factors that contribute to memory and learning is limited
by the complexity of brain development and the lack of suitable human models for mild …

Identification and characterization of multi-species conserved sequences

EH Margulies, M Blanchette, D Haussler… - Genome …, 2003 - genome.cshlp.org
Comparative sequence analysis has become an essential component of studies aiming to
elucidate genome function. The increasing availability of genomic sequences from multiple …

The DNA sequence of human chromosome 7

LDW Hillier, RS Fulton, LA Fulton, TA Graves… - Nature, 2003 - nature.com
Human chromosome 7 has historically received prominent attention in the human genetics
community, primarily related to the search for the cystic fibrosis gene and the frequent …

Identification and characterization of a novel monoamine transporter in the human brain

K Engel, M Zhou, J Wang - Journal of Biological Chemistry, 2004 - ASBMB
Precise control of monoamine neurotransmitter levels in the extracellular fluids of the brain is
critical in maintaining efficient and robust neurotransmission. High affinity transporters in the …

The (Pro)Renin Receptor: Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney

A Advani, DJ Kelly, AJ Cox, KE White, SL Advani… - …, 2009 - Am Heart Assoc
The (pro) renin receptor ([P] RR) is a transmembrane protein that binds both renin and
prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and …

Complex loci in human and mouse genomes

PG Engström, H Suzuki, N Ninomiya, A Akalin… - PLoS …, 2006 - journals.plos.org
Mammalian genomes harbor a larger than expected number of complex loci, in which
multiple genes are coupled by shared transcribed regions in antisense orientation and/or by …

Human protein factory for converting the transcriptome into an in vitro–expressed proteome

N Goshima, Y Kawamura, A Fukumoto, A Miura… - Nature …, 2008 - nature.com
Appropriate resources and expression technology necessary for human proteomics on a
whole-proteome scale are being developed. We prepared a foundation for simple and …