The genetic programs directing CD4 or CD8 T cell differentiation in the thymus remain
poorly understood. While analyzing gene expression during intrathymic T cell selection, we …

UV-sensitive syndrome (UVSS) is an autosomal recessive disorder characterized by
photosensitivity and deficiency in transcription-coupled repair (TCR), a subpathway of …

Despite the prevalence of insulin resistance and type 2 diabetes mellitus, their underlying
mechanisms remain incompletely understood. Many secreted endocrine factors and the …

The in vivo characterization of the exact copy number and the specific function of each
composite protein within the nuclear pore complex (NPC) remains both desirable and …

Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases
are characterized by neuronal accumulation of the disease protein, suggesting that the …

Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely
influence the development of chronic obstructive pulmonary disease (COPD). Linkage …

Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that
regulates gene expression by deacetylation of histones and nonhistone proteins. Early …

Essential effector functions of innate immunity are mediated by complement activation
initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL) and the …

Germline mutations involving small mothers against decapentaplegic–transforming growth
factor–β (SMAD–TGF-β) signaling are an important but rare cause of pulmonary arterial …

The human genome sequence defines our inherent biological potential; the realization of
the biology encoded therein requires knowledge of the function of each gene. Currently, our …