Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron
pool. The possibility of histidine and carnosine forming ternary complexes with iron (II) …

Eukaryotic cells contain hundreds of metalloproteins, and ensuring that each protein
receives the correct metal ion is a critical task for cells. Recent work in budding yeast and …

Cytosolic and nuclear iron-sulfur (Fe-S) proteins are involved in many essential pathways
including translation and DNA maintenance. Their maturation requires the cytosolic Fe-S …

Eukaryotic organisms have evolved a set of strategies to safeguard genome integrity, but the
underlying mechanisms remain poorly understood. Here, we report that ASYMMETRIC …

The mitochondrion is a major site for the metabolism of the transition metal, iron, which is
necessary for metabolic processes critical for cell vitality. The enigmatic mitochondrial …

Mitochondrial homeostasis is essential for maintaining healthy cellular function and survival.
The detrimental involvement of mitochondrial dysfunction in neuro-degenerative diseases …

In humans, the bulk of iron in the body (over 75%) is directed towards heme-or Fe–S cluster
cofactor synthesis, and the complex, highly regulated pathways in place to accomplish …

Isoprenoids, which are a large group of natural and chemical compounds with a variety of
applications as eg fragrances, pharmaceuticals and potential biofuels, are produced via two …

Microorganisms have to adapt their metabolism to the requirements of their ecological niche
to avoid iron shortage as well as iron toxicity. Therefore, mechanisms have been evolved to …

Despite their relative simplicity, iron–sulfur clusters have been omnipresent as cofactors in
myriad cellular processes such as oxidative phosphorylation and other respiratory …