[HTML][HTML] Structural and functional comparison of magnesium transporters throughout evolution

GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

[HTML][HTML] The genetic spectrum of Gitelman (-like) syndromes

KP Schlingmann, JHF de Baaij - Current opinion in nephrology …, 2022 - journals.lww.com
The genetic spectrum of Gitelman(-like) syndromes : Current Opinion in Nephrology and
Hypertension The genetic spectrum of Gitelman(-like) syndromes : Current Opinion in …

[HTML][HTML] Crystal structure of an archaeal CorB magnesium transporter

YS Chen, G Kozlov, BE Moeller, A Rohaim… - Nature …, 2021 - nature.com
CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …

PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics

S Hardy, Y Zolotarov, J Coleman… - Proceedings of the …, 2023 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2,
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …

Genetic and drug-induced hypomagnesemia: different cause, same mechanism

W Bosman, JGJ Hoenderop… - Proceedings of the …, 2021 - cambridge.org
Magnesium (Mg2+) plays an essential role in many biological processes. Mg2+ deficiency is
therefore associated with a wide range of clinical effects including muscle cramps, fatigue …

New insights into the structure and function of CNNM proteins

YS Chen, K Gehring - The FEBS Journal, 2023 - Wiley Online Library
Magnesium (Mg2+) is the most abundant divalent cation in cells and plays key roles in
almost all biological processes. CBS‐pair domain divalent metal cation transport mediators …

[HTML][HTML] Clinical and genetic approach to renal hypomagnesemia

MH Tseng, M Konrad, JJ Ding, SH Lin - Biomedical Journal, 2022 - Elsevier
Abstract Magnesium (Mg 2+) is an important intracellular cation and essential to maintain
cell function including cell proliferation, immunity, cellular energy metabolism, protein and …

Magnesium homeostasis: lessons from human genetics

AR Morrison - Clinical Journal of the American Society of …, 2023 - journals.lww.com
Mg 2+, the fourth most abundant cation in the body, serves as a cofactor for about 600
cellular enzymes. One third of ingested Mg 2+ is absorbed from the gut through a saturable …

[HTML][HTML] Hypomagnesaemia with varying degrees of extrarenal symptoms as a consequence of heterozygous CNNM2 variants

W Bosman, GAC Franken, J de Las Heras… - Scientific Reports, 2024 - nature.com
Variants in the CNNM2 gene are causative for hypomagnesaemia, seizures and intellectual
disability, although the phenotypes can be variable. This study aims to understand the …

[HTML][HTML] Hereditary kidney diseases associated with hypomagnesemia

F Claverie-Martin, A Perdomo-Ramirez… - Kidney research and …, 2021 - ncbi.nlm.nih.gov
In the kidney, a set of proteins expressed in the epithelial cells of the thick ascending loop of
Henle and the distal convoluted tubule directly or indirectly play important roles in the …