Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal
absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re) absorption …

GeoBioMed—a new transdisciplinary approach that integrates the fields of geology, biology
and medicine—reveals that kidney stones composed of calcium-rich minerals precipitate …

Central to the maintenance of calcium homeostasis is the regulated reabsorption of calcium
along the nephron. To this end, parathyroid hormone (PTH) is released from the parathyroid …

Calcium and magnesium are the most abundant divalent cations in the body. The plasma
level is controlled by coordinated interaction between intestinal absorption, reabsorption in …

Kidney stone disease (KSD) is one of the earliest medical diseases known, but the
mechanism of its formation and metabolic changes remain unclear. The formation of kidney …

Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …

Nephrolithiasis is a worldwide problem with increasing prevalence, enormous costs, and
significant morbidity. Calcium-containing kidney stones are by far the most common kidney …

Extracellular fluid calcium concentration must be maintained within a narrow range in order
to sustain many biological functions, encompassing muscle contraction, blood coagulation …