Assembling the adipose organ: adipocyte lineage segregation and adipogenesis in vivo
ZL Sebo, MS Rodeheffer - Development, 2019 - journals.biologists.com
Adipose tissue is composed of anatomically distinct depots that mediate several important
aspects of energy homeostasis. The past two decades have witnessed increased research …
aspects of energy homeostasis. The past two decades have witnessed increased research …
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
Abstract Characterization of the progression of cellular states during human embryogenesis
can provide insights into the origin of pediatric diseases. We examined the transcriptional …
can provide insights into the origin of pediatric diseases. We examined the transcriptional …
[HTML][HTML] Programmed cell senescence during mammalian embryonic development
D Muñoz-Espín, M Cañamero, A Maraver… - Cell, 2013 - cell.com
Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer
and aging. Here, we show that senescence occurs during mammalian embryonic …
and aging. Here, we show that senescence occurs during mammalian embryonic …
Recent findings on the role of microRNAs in genetic kidney diseases
Background MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–
25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated …
25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated …
[HTML][HTML] Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing
Recent advances in single-cell, transcriptomic profiling have provided unprecedented
access to investigate cell heterogeneity during tissue and organ development. In this study …
access to investigate cell heterogeneity during tissue and organ development. In this study …
Lin28 sustains early renal progenitors and induces Wilms tumor
A Urbach, A Yermalovich, J Zhang… - Genes & …, 2014 - genesdev.cshlp.org
Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal
differentiation of the embryonic kidney. Here we show that overexpression of the …
differentiation of the embryonic kidney. Here we show that overexpression of the …
Conserved and novel functions of programmed cellular senescence during vertebrate development
H Davaapil, JP Brockes, MH Yun - Development, 2017 - journals.biologists.com
Cellular senescence, a form of stable cell cycle arrest that is traditionally associated with
tumour suppression, has been recently found to occur during mammalian development …
tumour suppression, has been recently found to occur during mammalian development …
A mesodermal fate map for adipose tissue
The embryonic origin of distinct fat depots and the role for ontogeny in specifying the
functional differences among adipocyte lineages between and within depots is unclear …
functional differences among adipocyte lineages between and within depots is unclear …
Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators
Nephron endowment is determined by the self-renewal and induction of a nephron
progenitor pool established at the onset of kidney development. In the mouse, the related …
progenitor pool established at the onset of kidney development. In the mouse, the related …
Target delivery of drug carriers in mice kidney glomeruli via renal artery. Balance between efficiency and safety
ES Prikhozhdenko, OI Gusliakova, OA Kulikov… - Journal of Controlled …, 2021 - Elsevier
Targeting drug delivery systems is crucial to reducing the side effects of therapy. However,
many of them are lacking effectiveness for kidney targeting, due to systemic dispersion and …
many of them are lacking effectiveness for kidney targeting, due to systemic dispersion and …