Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

INTRODUCTION In cellular immunity, cytotoxic T lymphocytes (CTLs) and natural killer (NK)
cells use perforin to deliver serine protease granzymes into target cells to kill them …

NK cells eliminate virus-infected and tumor cells by releasing cytotoxic granules containing
granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The …

NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

Current natural killer (NK) cell-based cancer immunotherapy for the treatment of solid tumors
often exhibits insufficient cancer recognition specificity, thereby limiting therapeutic …

Background Glioblastoma (GBM) treatment is undermined by the suppressive tumor immune
microenvironment (TIME). Seek for effective methods for brain TIME modulation is a …

Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …

Cytotoxic lymphocytes are critical in our immune defence against cancer and infection.
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …