Cationic gemini surfactant properties, its potential as a promising bioapplication candidate, and strategies for improving its biocompatibility: A review

AR Ahmady, P Hosseinzadeh, A Solouk… - Advances in colloid and …, 2022 - Elsevier
Gemini surfactants consist of two cationic monomers of a surfactant linked together with a
spacer. The specific structure of a cationic gemini surfactant is the reason for both its high …

Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks

RX Zhang, T Ahmed, LY Li, J Li, AZ Abbasi, XY Wu - Nanoscale, 2017 - pubs.rsc.org
Polymer–lipid hybrid nanoparticles (PLN) are an emerging nanocarrier platform made from
building blocks of polymers and lipids. PLN integrate the advantages of biomimetic lipid …

Multifunctional gemini surfactants: structure, synthesis, properties and applications

BE Brycki, IH Kowalczyk, A Szulc… - Application and …, 2017 - books.google.com
Geminicationic surfactants are compounds which are composed of two hydrophilic head
groups and two hydrophobic tails linked by a spacer at the head groups or closed to them …

Multivalent calixarene-based liposomes as platforms for gene and drug delivery

JA Lebrón, M López-López, CB García-Calderón… - Pharmaceutics, 2021 - mdpi.com
The formation of calixarene-based liposomes was investigated, and the characterization of
these nanostructures was carried out using several techniques. Four amphiphilic …

Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers

H Xing, M Lu, T Yang, H Liu, Y Sun, X Zhao, H Xu… - Acta biomaterialia, 2019 - Elsevier
In recent years, substantial advances have been achieved in the design and synthesis of
nonviral gene vectors. However, lack of effective and biocompatible vectors still remains a …

Optimizing the design of blood–brain barrier-penetrating polymer-lipid-hybrid nanoparticles for delivering anticancer drugs to glioblastoma

T Ahmed, FCF Liu, C He, AZ Abbasi, P Cai… - Pharmaceutical …, 2021 - Springer
Purpose Chemotherapy for glioblastoma multiforme (GBM) remains ineffective due to
insufficient penetration of therapeutic agents across the blood–brain barrier (BBB) and into …

Clear distinction between CAC and CMC revealed by high-resolution NMR diffusometry for a series of bis-imidazolium gemini surfactants in aqueous solutions

K Szutkowski, Ż Kołodziejska, Z Pietralik, I Zhukov… - RSC …, 2018 - pubs.rsc.org
The aggregation behavior in the transition region was studied for a series of dicationic
surfactants 3, 3′-[α, ω-(dioxaalkane)] bis (1-dodecylimidazolium) dichlorides with varied …

Importance of hydrophobic interactions in the single-chained cationic surfactant-DNA complexation

M López-López, P López-Cornejo, VI Martín… - Journal of colloid and …, 2018 - Elsevier
The goal of this work was to understand the key factors determining the DNA compacting
capacity of single-chained cationic surfactants. Fluorescence, zeta potential, circular …

An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing …

T Ahmed, FCF Liu, XY Wu - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
Introduction Polymer-lipid hybrid nanoparticle (PLN) is an emerging nanoplatform with
distinct properties and functionalities from other nanocarrier systems. PLN can be optimized …

Exploring the binding mode of ester-based cationic gemini surfactants with calf thymus DNA: A detailed physicochemical, spectroscopic and theoretical study

M Akram, H Lal - Bioorganic Chemistry, 2022 - Elsevier
Gene therapy is a transfectant method for the treatment of hereditary disease, which
transfers the gene mutation into the cells. In the view of the high prospects of utilization of …