The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

V Carlini, DM Noonan, E Abdalalem, D Goletti… - Frontiers in …, 2023 - frontiersin.org
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

Inflammatory and vascular biomarkers in post‐COVID‐19 syndrome: A systematic review and meta‐analysis of over 20 biomarkers

SJ Yong, A Halim, M Halim, S Liu… - Reviews in medical …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 may inflict a post‐viral condition known as
post‐COVID‐19 syndrome (PCS) or long‐COVID. Studies measuring levels of inflammatory …

Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

H Bonilla, MJ Peluso, K Rodgers, JA Aberg… - Frontiers in …, 2023 - frontiersin.org
Although most individuals recover from acute SARS-CoV-2 infection, a significant number
continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

IL-10 as a Th2 cytokine: differences between mice and humans

MT Rasquinha, M Sur, N Lasrado… - The Journal of …, 2021 - journals.aai.org
The discovery of IL-10 more than 30 years ago marked the beginning of our understanding
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …

Dengue and COVID-19: two sides of the same coin

GN Malavige, C Jeewandara, GS Ogg - Journal of biomedical science, 2022 - Springer
Abstract Background Many countries in Asia and Latin America are currently facing a double
burden of outbreaks due to dengue and COVID-19. Here we discuss the similarities and …

Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical …

BSA Silva, T Pereira, LG Minuzzi, CS Padilha… - Frontiers in …, 2023 - frontiersin.org
Aim This study aimed to evaluate if physical activity is associated with systemic and cellular
immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection …

Inflammatory pathways in COVID‐19: mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

Pro-inflammatory and anti-inflammatory interleukins in infectious diseases: A comprehensive review

AA Al-Qahtani, FS Alhamlan, AA Al-Qahtani - Tropical medicine and …, 2024 - mdpi.com
Interleukins (ILs) are signaling molecules that are crucial in regulating immune responses
during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment …

Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19

KD Wick, A Leligdowicz, A Willmore, SA Carrillo… - Critical Care, 2022 - Springer
Abstract Background Studies quantifying SARS-CoV-2 have focused on upper respiratory
tract or plasma viral RNA with inconsistent association with clinical outcomes. The …