Electroresponsive hydrogels for therapeutic applications in the brain

ZM Khan, E Wilts, E Vlaisavljevich… - Macromolecular …, 2022 - Wiley Online Library
Electroresponsive hydrogels possess a conducting material component and respond to
electric stimulation through reversible absorption and expulsion of water. The high level of …

Stimuli-responsive polymeric nanocarriers for efficient gene delivery

Y Li, J Gao, C Zhang, Z Cao, D Cheng, J Liu… - Polymeric Gene Delivery …, 2018 - Springer
Gene therapy provides an alternative and effective method for treatment of genetic diseases
and cancers that are refractory to conventional therapeutics. The success of gene therapy is …

Pharmaco-genetic therapeutics targeting parvalbumin neurons attenuate temporal lobe epilepsy

Y Wang, J Liang, L Chen, Y Shen, J Zhao, C Xu… - Neurobiology of …, 2018 - Elsevier
Temporal lobe epilepsy (TLE) is the most common type of epilepsy and is often medically
refractory. Previous studies suggest that selective pharmaco-genetic inhibition of pyramidal …

[HTML][HTML] Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid …

B Feng, Y Tang, B Chen, C Xu, Y Wang, Y Dai, D Wu… - Scientific Reports, 2016 - nature.com
It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility.
Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS …

[HTML][HTML] Development of targeted therapies in treatment of glioblastoma

YY Xu, P Gao, Y Sun, YR Duan - Cancer biology & medicine, 2015 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy.
Standard therapeutic approaches provide modest improvement in progression-free and …

[图书][B] Encyclopedia of Polymer Applications, 3 Volume Set

M Mishra - 2018 - taylorfrancis.com
Undoubtedly the applications of polymers are rapidly evolving. Technology is continually
changing and quickly advancing as polymers are needed to solve a variety of day-to-day …

Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy

C Xu, YI Wang, S Zhang, J Nao, Y Liu… - Annals of …, 2019 - Wiley Online Library
Objective Drug‐resistant epilepsy causes great clinical danger and still lacks effective
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …

[HTML][HTML] Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against …

Y Wu, A Angelova - Nanomaterials, 2023 - mdpi.com
The lack of effective treatments for neurodegenerative diseases (NDs) is an important
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …

[HTML][HTML] Fighting Epilepsy with Nanomedicines—Is This the Right Weapon?

M Matias, AO Santos, S Silvestre, G Alves - Pharmaceutics, 2023 - mdpi.com
Epilepsy is a chronic and complex condition and is one of the most common neurological
diseases, affecting about 50 million people worldwide. Pharmacological therapy has been …

D‐peptides as recognition molecules and therapeutic agents

M Liu, X Li, Z Xie, C Xie, C Zhan, X Hu… - The Chemical …, 2016 - Wiley Online Library
Over recent years, D‐peptides have attracted increasing attention. D‐peptides increase
enzymatic stability, prolong the plasma half‐life, improve oral bioavailability, and enhance …