Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Mapping single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
[HTML][HTML] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
SARS-CoV-2-specific T cells in infection and vaccination
During viral infections, antibodies and T cells act together to prevent pathogen spread and
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …
[HTML][HTML] Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …
variation to disease severity and outcome over time, we longitudinally assessed circulating …
Single-cell immunology of SARS-CoV-2 infection
Gaining a better understanding of the immune cell subsets and molecular factors associated
with protective or pathological immunity against severe acute respiratory syndrome …
with protective or pathological immunity against severe acute respiratory syndrome …
[HTML][HTML] B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
The long non-coding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in
female cells in early development and thereafter is thought to be largely dispensable. Here …
female cells in early development and thereafter is thought to be largely dispensable. Here …
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity
M Saichi, MZ Ladjemi, S Korniotis, C Rousseau… - Nature Cell …, 2021 - nature.com
COVID-19 can lead to life-threatening respiratory failure, with increased inflammatory
mediators and viral load. Here, we perform single-cell RNA-sequencing to establish a high …
mediators and viral load. Here, we perform single-cell RNA-sequencing to establish a high …
Immunogenic and reactogenic efficacy of Covaxin and Covishield: a comparative review
S Das, SS Kar, S Samanta, J Banerjee, B Giri… - Immunologic …, 2022 - Springer
SARS-CoV-2 is an RNA virus that was identified for the first time in December 2019 in
Wuhan, China. The World Health Organization (WHO) labeled the novel coronavirus …
Wuhan, China. The World Health Organization (WHO) labeled the novel coronavirus …