The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature

A Ishak, M Mehendale, MM AlRawashdeh… - Gene, 2022 - Elsevier
Background COVID-19 is associated with several risk factors such as distinct ethnicities
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …

Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection

SMA Hashemi, M Thijssen, SY Hosseini, A Tabarraei… - Archives of …, 2021 - Springer
The SARS-CoV-2 pandemic has become one of the most serious health concerns globally.
Although multiple vaccines have recently been approved for the prevention of coronavirus …

SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease

N Alimoradi, M Sharqi, D Firouzabadi, MM Sadeghi… - Virology Journal, 2022 - Springer
COVID-19 and the renin-angiotensin system (RAS) are linked by angiotensin-converting
enzyme 2 (ACE2), a key enzyme in RAS that has been validated as a SARS-CoV-2 receptor …

ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

LE Martinez-Gomez, B Herrera-Lopez… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries …

Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease

M Sabater Molina, E Nicolas Rocamora, AI Bendicho… - PloS one, 2022 - journals.plos.org
Background Infection by the SARS-Cov-2 virus produces in humans a disease of highly
variable and unpredictable severity. The presence of frequent genetic single nucleotide …

Association of TMPRSS2 Gene Polymorphisms with COVID-19 Severity and Mortality: a Case-Control Study with Computational Analyses

M Rokni, M Heidari Nia, M Sarhadi, S Mirinejad… - Applied biochemistry …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a severe disease caused by a new
variant of beta-coronavirus that first appeared in China. Human genetic factors, including …

The renin-angiotensin system: a key role in SARS-CoV-2-induced COVID-19

G El-Arif, A Farhat, S Khazaal, C Annweiler, H Kovacic… - Molecules, 2021 - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative
agent of coronavirus disease 2019 (COVID-19), was first identified in Eastern Asia (Wuhan …

Human genetic basis of coronavirus disease 2019

H Deng, X Yan, L Yuan - Signal transduction and targeted therapy, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable …

The impact of ACE and ACE2 gene polymorphisms in pulmonary diseases including COVID-19

I Gintoni, M Adamopoulou, C Yapijakis - in vivo, 2022 - iv.iiarjournals.org
Chronic and acute respiratory diseases pose a major problem for public health worldwide
due to the high morbidity and mortality rates, while treatment options remain mostly …

[HTML][HTML] ACE2 and TMPRSS2 SNPs as Determinants of Susceptibility to, and Severity of, a COVID-19 Infection

S Abdelsattar, ZA Kasemy, SF Ewida… - British Journal of …, 2022 - frontierspartnerships.org
Background: Genetic risk factors may be related to the infectivity and severity of SARS-CoV-
2 infection. Angiotensin-converting enzyme 2 (ACE2) and host transmembrane serine …