New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study

T Pillinger, EF Osimo, A de Marvao, M Shah… - The Lancet …, 2023 - thelancet.com
Background Cardiovascular disease is a major cause of excess mortality in people with
schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of …

[HTML][HTML] Dysbindin-1, BDNF, and GABAergic transmission in schizophrenia

R Jun, W Zhang, NJ Beacher, Y Zhang, Y Li… - Frontiers in …, 2022 - frontiersin.org
Schizophrenia is a psychiatric disorder characterized by hallucinations, anhedonia,
disordered thinking, and cognitive impairments. Both genetic and environmental factors …

Schizophrenia: a developmental disorder with a risk of non-specific but avoidable decline

RM Murray, E Bora, G Modinos, A Vernon - Schizophrenia Research, 2022 - Elsevier
The onset of schizophrenia is determined by biological and social risk factors operating
predominantly during development. These result in subtle deviations in brain structure and …

[HTML][HTML] Schizophrenia and co-morbidity risk: evidence from a data driven phenomewide association study

A Mulugeta, V Suppiah, E Hyppönen - Journal of Psychiatric Research, 2023 - Elsevier
Schizophrenia is a chronic debilitating psychiatric disorder with significant morbidity and
mortality. In this study, we used information from 337,484 UK Biobank participants and …

Schizophrenia: genetic insights with clinical potential

OB Smeland, OA Andreassen - Nature Reviews Neurology, 2022 - nature.com
Schizophrenia: genetic insights with clinical potential | Nature Reviews Neurology Skip to
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Correlations between schizophrenia and lichen planus: a two-sample bidirectional Mendelian randomization study

GY Chen, L Fu, B Ye, M Ao, M Yan, HC Feng - Frontiers in Psychiatry, 2023 - frontiersin.org
Background Several existing studies have shown a correlation between schizophrenia and
lichen planus (LP). However, the causality of this relationship remains uncertain. Thus, this …

Schizophrenia, human leukocyte antigen (HLA), and herpes viruses: immunogenetic associations at the population level

LM James, SA Charonis… - Neuroscience …, 2023 - journals.sagepub.com
Several factors have been implicated in schizophrenia (SZ), including human herpes viruses
(HHV) and the adaptive immunity Human Leukocyte Antigen (HLA) genes. Here we …

[HTML][HTML] Association between brain similarity to severe mental illnesses and comorbid cerebral, physical, and cognitive impairments

Y Ma, MD Kvarta, BM Adhikari, J Chiappelli, X Du… - Neuroimage, 2023 - Elsevier
Severe mental illnesses (SMIs) are often associated with compromised brain health,
physical comorbidities, and cognitive deficits, but it is incompletely understood whether …

Prevalence and Influence Factors for Non-Alcoholic Fatty Liver Disease in Long-Term Hospitalized Patients with Schizophrenia: A Cross-Sectional Retrospective …

X Li, Y Gao, Y Wang, Y Wang, Q Wu - … Disease and Treatment, 2023 - Taylor & Francis
Purpose Long-term hospitalized patients with schizophrenia (SCZ) are vulnerable to
physical illness, leading to impaired life expectancy and treatment outcomes. There are few …