Understanding chronic venous disease: a critical overview of its pathophysiology and medical management

MA Ortega, O Fraile-Martínez… - Journal of clinical …, 2021 - mdpi.com
Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy

S Kraler, MC Blaser, E Aikawa, GG Camici… - European heart …, 2022 - academic.oup.com
Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Reduced vitamin K status as a potentially modifiable risk factor of severe coronavirus disease 2019

ASM Dofferhoff, I Piscaer, LJ Schurgers… - Clinical Infectious …, 2021 - academic.oup.com
Background Respiratory failure and thromboembolism are frequent in severe acute
respiratory syndrome coronavirus 2–infected patients. Vitamin K activates both hepatic …

Cardiovascular calcification heterogeneity in chronic kidney disease

JD Hutcheson, C Goettsch - Circulation research, 2023 - Am Heart Assoc
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for
cardiovascular disease, particularly ischemic heart disease, due to premature vascular and …

The role of vitamin K in humans: implication in aging and age-associated diseases

DS Popa, G Bigman, ME Rusu - Antioxidants, 2021 - mdpi.com
As human life expectancy is rising, the incidence of age-associated diseases will also
increase. Scientific evidence has revealed that healthy diets, including good fats, vitamins …

An update on vascular calcification and potential therapeutics

A Singh, S Tandon, C Tandon - Molecular Biology Reports, 2021 - Springer
Pathological calcification is a major cause of cardiovascular morbidities primarily in
population with chronic kidney disease (CKD), end stage renal diseases (ERSD) and …

Accelerated vascular aging in chronic kidney disease: the potential for novel therapies

S Hobson, S Arefin, A Witasp, L Hernandez… - Circulation …, 2023 - Am Heart Assoc
The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

Targeting a silent disease: vascular calcification in chronic kidney disease

C Marreiros, C Viegas, D Simes - International Journal of Molecular …, 2022 - mdpi.com
Chronic kidney disease (CKD) patients have a higher risk of developing early
cardiovascular disease (CVD). Although vascular calcification (VC) is one of the strongest …

Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications

R Kaur, R Singh - Life Sciences, 2022 - Elsevier
Abstract Chronic Kidney Disease (CKD) is linked to a rising prevalence of morbidity and
mortality primarily from cardiovascular complications and is considered a high or very high …

Intimal and medial calcification in relation to cardiovascular risk factors

SR Zwakenberg, PA de Jong, EJ Hendriks… - PLoS …, 2020 - journals.plos.org
Purpose To assess specific risk factors and biomarkers associated with intimal arterial
calcification (IAC) and medial arterial calcification (MAC). Methods We conducted a cross …