Targeting inhibitory immune checkpoint molecules has dramatically changed treatment
paradigms in medical oncology. Understanding the best strategies to unleash a pre-existing …

Over the past few decades, different inhibitory receptors have been identified, which have
played prominent roles in reducing anti-tumor immune responses. The role of immune …

Simple Summary The cytotoxic T cell response against hepatocellular carcinoma antigens is
exhausted and fails in its task of deleting tumoral cells. These cells are featured by the …

Background Although PD-1 has been reported to be a marker of T-cell exhaustion in several
malignancies, the biological role of PD-1+ CD8+ T cells in gastric cancer (GC) remains …

Background The mechanism by which immune cells regulate metastasis is unclear.
Understanding the role of immune cells in metastasis will guide the development of …

Background: Cancer patients often display dysfunctional antitumor T-cell responses.
Because noteworthy benefits of immune checkpoint pathway blockade, such as …

Cancers evade immune surveillance, which can be reversed through immune-checkpoint
therapy in a small subset of cases. Here, we report that the MYC oncogene suppresses …

T cells play a crucial role in the regulation of immune response and are integral to the
efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising …

The tumor immune microenvironment (TIME) in high-grade glioma (HGG) exhibits high
spatial heterogeneity. Though the tumor core and peripheral regions have different …

The liver is endowed with an amazing regenerative capacity that allows it to withstand an
enormous amount of damage. Nevertheless, it is precisely this highly regenerative capacity …