Conclusion The IMX-SEV-2 classifier showed a superior prediction of in-hospital mortality
compared to biomarkers and clinical scores among ED patients with suspected infections …

Although the precise clinical indication for initiation of PMX-HA is widely debated in the
literature, a proper patient selection and timing of treatment delivery might play a critical role …

Acute on chronic liver failure (ACLF) reflects the development of organ failure (s) in a patient
with cirrhosis and is associated with high short‐term mortality. Given that ACLF has many …

Background Sepsis-induced acute kidney injury (S-AKI) is an inflammatory disease with sex
differences and there has no effective drugs to cure it. Frehmaglutin D (Fre D) and …

OBJECTIVES: To identify research priorities in the management, epidemiology, outcome,
and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the …

Liver, as an immune and detoxification organ, represents an important line of defense
against bacteria and infection and a vulnerable organ that is easily injured during sepsis …

Sepsis is a life-threatening condition resulting from an inflammatory overreaction that is
induced by an infectious factor, which leads to multi-organ failure. Sepsis-associated …

Background In recent years, numerous dosing studies have been conducted to optimize
therapeutic antibiotic exposures in patients with serious infections. These studies have led to …

Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious
disease caused by Leptospira spp., as well as a reemerging disease and global public …

The incidence rates of sepsis and septic shock as a complication have become more
common over the past several decades. With this increase, sepsis remains the most …