Immune mediators in the brain and peripheral tissues in autism spectrum disorder

ML Estes, AK McAllister - Nature Reviews Neuroscience, 2015 - nature.com
Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

[HTML][HTML] The cerebellar involvement in autism spectrum disorders: from the social brain to mouse models

L Mapelli, T Soda, E D'Angelo, F Prestori - International journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …

Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition

W Mandy, MC Lai - Journal of Child Psychology and Psychiatry, 2016 - Wiley Online Library
Background Although autism spectrum condition (ASC) is strongly genetic in origin,
accumulating evidence points to the critical roles of various environmental influences on its …

[HTML][HTML] The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior

T Arentsen, Y Qian, S Gkotzis, T Femenia, T Wang… - Molecular …, 2017 - nature.com
Recent studies have revealed that the gut microbiota modulates brain development and
behavior, but the underlying mechanisms are still poorly understood. Here, we show that …

[HTML][HTML] Striatal circuits as a common node for autism pathophysiology

MV Fuccillo - Frontiers in neuroscience, 2016 - frontiersin.org
Autism spectrum disorders (ASD) are characterized by two seemingly unrelated symptom
domains—deficits in social interactions and restrictive, repetitive patterns of behavioral …

[HTML][HTML] Autism spectrum disorders and autistic traits share genetics and biology

J Bralten, KJ Van Hulzen, MB Martens… - Molecular …, 2018 - nature.com
Autism spectrum disorders (ASDs) and autistic traits in the general population may share
genetic susceptibility factors. In this study, we investigated such potential overlap based on …

[HTML][HTML] HGF and MET: from brain development to neurological disorders

C Desole, S Gallo, A Vitacolonna… - Frontiers in Cell and …, 2021 - frontiersin.org
Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET
cellular proto-oncogene, are expressed in the nervous system from pre-natal development …

Unexpected roles for the second brain: enteric nervous system as master regulator of bowel function

S Schneider, CM Wright… - Annual review of …, 2019 - annualreviews.org
At the most fundamental level, the bowel facilitates absorption of small molecules, regulates
fluid and electrolyte flux, and eliminates waste. To successfully coordinate this complex …

[HTML][HTML] A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder

R Lefter, A Ciobica, D Timofte, C Stanciu, A Trifan - Medicina, 2019 - mdpi.com
Background and Objectives: Gastrointestinal disturbances have been frequently, but not
unanimously, reported in autism spectrum disorder (ASD) individuals. Thus, digestive …

[HTML][HTML] Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder

S Nisar, M Haris - Molecular psychiatry, 2023 - nature.com
Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early
childhood and are characterized by qualitative abnormalities in social behaviors …