Epigenetics of alcohol use disorder—A review of recent advances in DNA methylation profiling

MJ Longley, J Lee, J Jung, FW Lohoff - Addiction biology, 2021 - Wiley Online Library
Alcohol use disorder (AUD) is a major contributor to morbidity and mortality worldwide.
Although there is a heritable component, the etiology of AUD is complex and can involve …

EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study

Z Xiong, F Yang, M Li, Y Ma, W Zhao… - Nucleic Acids …, 2022 - academic.oup.com
Abstract Epigenome-Wide Association Study (EWAS) has become a standard strategy to
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …

Applications of artificial intelligence to improve patient flow on mental health inpatient units-Narrative literature review

P Cecula, J Yu, FM Dawoodbhoy, J Delaney, J Tan… - Heliyon, 2021 - cell.com
Background Despite a growing body of research into both Artificial intelligence and mental
health inpatient flow issues, few studies adequately combine the two. This review …

AI in patient flow: applications of artificial intelligence to improve patient flow in NHS acute mental health inpatient units

FM Dawoodbhoy, J Delaney, P Cecula, J Yu, I Peacock… - Heliyon, 2021 - cell.com
Introduction Growing demand for mental health services, coupled with funding and resource
limitations, creates an opportunity for novel technological solutions including artificial …

Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the …

FW Lohoff, TK Clarke, ZA Kaminsky, RM Walker… - Molecular …, 2022 - nature.com
Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …

Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension

N Carreras-Gallo, VB Dwaraka, A Cáceres, R Smith… - Epigenetics, 2023 - Taylor & Francis
Tobacco, alcohol, and marijuana consumption is an important public health problem
because of their high use worldwide and their association with the risk of mortality and many …

[HTML][HTML] Additive effects of stress and alcohol exposure on accelerated epigenetic aging in alcohol use disorder

J Jung, DL McCartney, J Wagner, J Yoo, AS Bell… - Biological …, 2023 - Elsevier
Background Stress contributes to premature aging and susceptibility to alcohol use disorder
(AUD), and AUD itself is a factor in premature aging; however, the interrelationships of …

A new monocyte epigenetic clock reveals nonlinear effects of alcohol consumption on biological aging in three independent cohorts (N = 2242)

X Liang, R Sinha, AC Justice, MH Cohen… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Assessing the effect of alcohol consumption on biological age is essential for
understanding alcohol use‐related comorbidities and mortality. Previously developed …

Dual methylation and hydroxymethylation study of alcohol use disorder

SL Clark, RF Chan, M Zhao, LY Xie… - Addiction …, 2022 - Wiley Online Library
Using an integrative, multi‐tissue design, we sought to characterize methylation and
hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD) …

Significantly elevated phosphatidylethanol levels in recent suicide attempters, but not in depressed controls and healthy volunteers

R Strumila, A Lengvenyte, L Zdanavicius… - Journal of Psychiatric …, 2023 - Elsevier
Introduction Suicide is a complex transdiagnostic phenomenon. It is strongly associated
with, but not exclusive to major depressive disorder (MDD). Hazardous alcohol drinking has …