Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?

C Jung, D Kmiec, L Koepke, F Zech, T Jacob… - Journal of …, 2022 - Am Soc Microbiol
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost

J Ai, H Zhang, Y Zhang, K Lin, Y Zhang… - Emerging microbes & …, 2022 - Taylor & Francis
The emerging new VOC B. 1.1. 529 (Omicron) variant has raised serious concerns due to
multiple mutations, reported significant immune escape, and unprecedented rapid …

[HTML][HTML] Reduced neutralization of SARS-CoV-2 B. 1.617 by vaccine and convalescent serum

C Liu, HM Ginn, W Dejnirattisai, P Supasa, B Wang… - Cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone
progressive change, with variants conferring advantage rapidly becoming dominant …

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

Y Liu, J Liu, BA Johnson, H Xia, Z Ku, C Schindewolf… - Cell reports, 2022 - cell.com
We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike
mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the …

Evidence of escape of SARS-CoV-2 variant B. 1.351 from natural and vaccine-induced sera

D Zhou, W Dejnirattisai, P Supasa, C Liu, AJ Mentzer… - Cell, 2021 - cell.com
The race to produce vaccines against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) began when the first sequence was published, and this forms the basis for …

[HTML][HTML] Antibody evasion by the P. 1 strain of SARS-CoV-2

W Dejnirattisai, D Zhou, P Supasa, C Liu, AJ Mentzer… - Cell, 2021 - cell.com
Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current
vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates …

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

X Xie, Y Liu, J Liu, X Zhang, J Zou, CR Fontes-Garfias… - Nature medicine, 2021 - nature.com
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viruses containing key spike mutations from the newly emerged United Kingdom (UK) and …

BNT162b2-elicited neutralization of B. 1.617 and other SARS-CoV-2 variants

J Liu, Y Liu, H Xia, J Zou, SC Weaver, KA Swanson… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve
around the world, generating new variants that are of concern on the basis of their potential …

The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

Y Liu, J Liu, KS Plante, JA Plante, X Xie, X Zhang, Z Ku… - Nature, 2022 - nature.com
Abstract The B. 1.1. 7 variant (also known as Alpha) of SARS-CoV-2, the cause of the COVID-
19 pandemic, emerged in the UK in the summer of 2020. The prevalence of this variant …