Overlapping genetic architecture between Parkinson disease and melanoma
Epidemiologic studies have reported inconsistent results regarding an association between
Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic …
Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic …
Multi‐omics cannot replace sample size in genome‐wide association studies
The integration of multi‐omics information (eg, epigenetics and transcriptomics) can be
useful for interpreting findings from genome‐wide association studies (GWAS). It has been …
useful for interpreting findings from genome‐wide association studies (GWAS). It has been …
Prioritising causal genes at type 2 diabetes risk loci
AK Grotz, AL Gloyn, SK Thomsen - Current diabetes reports, 2017 - Springer
Abstract Purpose of Review Genome-wide association studies (GWAS) for type 2 diabetes
(T2D) risk have identified a large number of genetic loci associated with disease …
(T2D) risk have identified a large number of genetic loci associated with disease …
Integration of machine learning methods to dissect genetically imputed transcriptomic profiles in Alzheimer's disease
The genetic component of many common traits is associated with the gene expression and
several variants act as expression quantitative loci, regulating the gene expression in a …
several variants act as expression quantitative loci, regulating the gene expression in a …
Rewiring of gene expression in circulating white blood cells is associated with pregnancy outcome in heifers (Bos taurus)
Infertility is a challenging phenomenon in cattle that reduces the sustainability of beef
production worldwide. Here, we tested the hypothesis that gene expression profiles of …
production worldwide. Here, we tested the hypothesis that gene expression profiles of …
A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies
Transcriptome-wide association studies (TWASs) integrate expression quantitative trait loci
(eQTLs) studies with genome-wide association studies (GWASs) to prioritize candidate …
(eQTLs) studies with genome-wide association studies (GWASs) to prioritize candidate …
[PDF][PDF] Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies
Transcriptome-wide association studies (TWASs) are a powerful approach to identify genes
whose expression is associated with complex disease risk. However, non-causal genes can …
whose expression is associated with complex disease risk. However, non-causal genes can …
Cis-and trans-eQTL TWASs of breast and ovarian cancer identify more than 100 susceptibility genes in the BCAC and OCAC consortia
ST Head, F Dezem, A Todor, J Yang, J Plummer… - The American Journal of …, 2024 - cell.com
Transcriptome-wide association studies (TWASs) have investigated the role of genetically
regulated transcriptional activity in the etiologies of breast and ovarian cancer. However …
regulated transcriptional activity in the etiologies of breast and ovarian cancer. However …
A genome-wide association study of total child psychiatric problems scores
Substantial genetic correlations have been reported across psychiatric disorders and
numerous cross-disorder genetic variants have been detected. To identify the genetic …
numerous cross-disorder genetic variants have been detected. To identify the genetic …
[PDF][PDF] Powerful eQTL mapping through low-coverage RNA sequencing
Mapping genetic variants that regulate gene expression (eQTL mapping) in large-scale RNA
sequencing (RNA-seq) studies is often employed to understand functional consequences of …
sequencing (RNA-seq) studies is often employed to understand functional consequences of …