Background—Chronic heart failure is characterized by left ventricular remodeling and
reactivation of a fetal gene program; the underlying mechanisms are only partly understood …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease.
HCM is a highly complex and heterogeneous disease regarding not only the number of …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

The heart, more than any other organ, requires precise functionality on a second-to-second
basis throughout the lifespan of the organism. Even subtle perturbations in cardiac structure …

The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-
dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that …

Since their discovery as key regulators of early animal development, microRNAs now are
recognized as widespread regulators of gene expression. Despite their abundance, little is …

MicroRNAs (miRNAs) are a class of highly conserved, noncoding RNAs involved in
posttranscriptional gene regulation. A small number of muscle-specific miRNAs have been …

Cell fate decisions of pluripotent embryonic stem (ES) cells are dictated by activation and
repression of lineage-specific genes. Numerous signaling and transcriptional networks …

Abstract microRNAs (miRNAs) are an abundant class of newly identified endogenous non‐
protein‐coding small RNAs. They exist in animals, plants, and viruses, and play an important …

MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of
genetic information by controlling translation or stability of mRNAs. Recent recognition that …