SARS-CoV-2 biology and host interactions

S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Evolution of the SARS-CoV-2 Omicron spike

RJ Parsons, P Acharya - Cell reports, 2023 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern, first identified in November 2021, rapidly spread worldwide and diversified into …

Human transferrin receptor can mediate SARS-CoV-2 infection

Z Liao, C Wang, X Tang, M Yang… - Proceedings of the …, 2024 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been
detected in almost all organs of coronavirus disease-19 patients, although some organs do …

USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice

F Dang, L Bai, J Dong, X Hu, J Wang… - Science Translational …, 2023 - science.org
Targeting angiotensin-converting enzyme 2 (ACE2) represents a promising and effective
approach to combat not only the COVID-19 pandemic but also potential future pandemics …

Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1

I Khan, S Li, L Tao, C Wang, B Ye, H Li, X Liu… - Nature …, 2024 - nature.com
SARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2
(ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor. Here, we screened …

[HTML][HTML] Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein

Z Yao, L Zhang, Y Duan, X Tang, J Lu - Journal of Infection, 2024 - Elsevier
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has substantially damaged the global economy and human health. The …

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

M McCallum, YJ Park, C Stewart, KR Sprouse… - Cell, 2024 - cell.com
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans
and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis …

Novel omicron variants enhance anchored recognition of TMEM106B: a new pathway for SARS-CoV-2 cellular invasion

X Zhao, F Gao - The Journal of Physical Chemistry Letters, 2024 - ACS Publications
The recent discovery that TMEM106B serves as a receptor mediating ACE2-independent
SARS-CoV-2 entry into cells deserves attention, especially in the background of the frequent …

The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication

J Li, Q Gui, FX Liang, J Sall, Q Zhang, Y Duan… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses,
replicates their genome in virus-induced cytosolic membrane-bound replication organelles …

[PDF][PDF] Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms …

HL Wang, R Siow, T Schmauck-Medina… - The Journals of …, 2024 - academic.oup.com
Unhealthy aging poses a global challenge with profound healthcare and socioeconomic
implications. Slowing down the aging process offers a promising approach to reduce the …