The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …

Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …

Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

The desirable curative effect in clinical immunotherapy has been challenging due to the
immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism in …

Background Systemic therapies have improved the management of hepatocellular
carcinoma, but there is still a need to further enhance overall survival in first-line advanced …

Objective We previously reported a characterisation of the hepatocellular carcinoma (HCC)
immune contexture and described an immune-specific class. We now aim to further …