Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis

S Zhong, J Lou, K Ma, Z Shu, L Chen, C Li, Q Ye… - Brain Imaging and …, 2023 - Springer
The microstructural characteristics of white and gray matter in mild cognitive impairment
(MCI) and the early-stage of Alzheimer's disease (AD) remain unclear. This study aimed to …

[HTML][HTML] Maintaining brain health across the lifespan

I Garcia-Garcia, O Donica, AA Cohen… - Neuroscience & …, 2023 - Elsevier
Across the lifespan, the human body and brain endure the impact of a plethora of
exogenous and endogenous factors that determine the health outcome in old age. The …

MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging

KA Walker, MR Duggan, Z Gong… - Annals of Clinical …, 2023 - Wiley Online Library
Objective White matter damage is a feature of Alzheimer's disease, yet little is known about
how facets of the Alzheimer's disease process relate to key features of white matter structure …

[HTML][HTML] Identification of clinically relevant brain endothelial cell biomarkers in plasma

J Cordon, MR Duggan, GT Gomez, KA Pucha, Z Peng… - Stroke, 2023 - journals.lww.com
BACKGROUND: Proteins expressed by brain endothelial cells (BECs), the primary cell type
of the blood-brain barrier, may serve as sensitive plasma biomarkers for neurological and …

Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals

Z Gong, M Bilgel, M Kiely, C Triebswetter… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction The influence of myelination on longitudinal changes in cognitive performance
remains unclear. Methods For each participant (N= 123), longitudinal cognitive scores were …

Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features

KG Schilling, D Archer, F Rheault, I Lyu, Y Huo… - Brain Structure and …, 2023 - Springer
Superficial white matter (SWM) represents a significantly understudied part of the human
brain, despite comprising a large portion of brain volume and making up a majority of cortico …

Association of poor oral health with neuroimaging markers of white matter injury in middle-aged participants in the UK Biobank

CA Rivier, DB Renedo, A de Havenon, NA Sunmonu… - Neurology, 2024 - AAN Enterprises
Background and Objectives Poor oral health is a modifiable risk factor that is associated with
clinically observed cardiovascular disease. However, the relationship between oral and …

[HTML][HTML] Distinct longitudinal brain white matter microstructure changes and associated polygenic risk of common psychiatric disorders and Alzheimer's disease in the …

M Korbmacher, D van der Meer, D Beck… - … Psychiatry Global Open …, 2024 - Elsevier
Background During the course of adulthood and aging, white matter (WM) structure and
organization are characterized by slow degradation processes such as demyelination and …

Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging

DB Archer, K Schilling, N Shashikumar… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction It is unclear how rates of white matter microstructural decline differ between
normal aging and abnormal aging. Methods Diffusion MRI data from several well …

Choir singing is associated with enhanced structural connectivity across the adult lifespan

N Moisseinen, L Ahveninen… - Human Brain …, 2024 - Wiley Online Library
The global ageing of populations calls for effective, ecologically valid methods to support
brain health across adult life. Previous evidence suggests that music can promote white …