Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
[HTML][HTML] The role of the immune system in posttraumatic stress disorder
S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
[HTML][HTML] Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
JH Krystal, AP Kaye, S Jefferson… - Proceedings of the …, 2023 - National Acad Sciences
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
[HTML][HTML] Transcriptional dissection of symptomatic profiles across the brain of men and women with depression
S Mansouri, AM Pessoni, A Marroquín-Rivera… - Nature …, 2023 - nature.com
Major depressive disorder (MDD) is one of the most important causes of disability
worldwide. While recent work provides insights into the molecular alterations in the brain of …
worldwide. While recent work provides insights into the molecular alterations in the brain of …
[HTML][HTML] Genetic insights into the neurobiology of anxiety
MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
Current and future directions of drug delivery for the treatment of mental illnesses
Mental illnesses including anxiety disorders, autism spectrum disorder, post-traumatic stress
disorder, schizophrenia, depression, and others exact an immense toll on the healthcare …
disorder, schizophrenia, depression, and others exact an immense toll on the healthcare …
[HTML][HTML] Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …