Clinically approved antiviral drugs are currently available for only 10 of the more than 220
viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need …

The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

Reducing the burden of infectious diseases that affect people in the developing world
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …

Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

Use of PZQ will increase in the foreseeable future, whether given alone or coadministered
with other anthelminthics in integrated control programmes. PZQ resistance remains a threat …

In global health, critical challenges have arisen from infectious diseases, including the
emergence and reemergence of old and new infectious diseases. Emergence and …

To enable the establishment of a drug discovery operation for neglected diseases, out of 2.3
million commercially available compounds 222 552 compounds were selected for an in …

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma
and Leishmania, which are human pathogens with devastating health and economic effects …

Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …