ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several
malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are …

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early
diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition …

Abstract The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) requires a rapid solution and global …

Malnutrition affects up to one billion people in the world and is a major cause of mortality,. In
many cases, malnutrition is associated with diarrhoea and intestinal inflammation, further …

Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related
to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For …

We report here the discovery and characterization of a gene, ELABELA (ELA), encoding a
conserved hormone of 32 amino acids. Present in human embryonic stem cells, ELA is …

Introduction Embryogenesis is thought to be directed by a small number of signaling
pathways with most if not all embryonic signals having been identified. However, the …