Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …

In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

Posttranslational modifications of histone N-terminal tails impact chromatin structure and
gene transcription. While the extent of histone acetylation is determined by both …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Genome editing critically relies on selective recognition of target sites. However, despite
recent progress, the underlying search mechanism of genome-editing proteins is not fully …

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA …

Epigenetic modification refers to heritable changes in gene function that cannot be
explained by alterations in the DNA sequence. The current literature clearly demonstrates …

The organization of eukaryotic chromatin has a major impact on all nuclear processes
involving DNA substrates. Gene expression is affected by the positioning of individual …

It has been established that regulation of chromatin structure through post-translational
modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an …