During infection, Mycobacterium tuberculosis colonizes macrophages or necrotic
granulomas, in which low pH is one of the major challenges. The PhoPR two-component …

Highlights•Genomic and transcriptional analyses have paved the way to study
Mycobacterium tuberculosis (Mtb) at a molecular level.•Shotgun-MS, S/MRM and …

The establishment of Mycobacterium tuberculosis (Mtb) long-term infection in vivo depends
on several factors, one of which is the availability of key nutrients such as iron (Fe). The …

Survival response of the human tuberculosis pathogen, Mycobacterium tuberculosis (Mtb) to
a diverse environmental cues is governed through its versatile transcription regulatory …

Tuberculosis is one of the deadliest infectious diseases worldwide and the prevalence of
latent tuberculosis acts as a huge roadblock in the global effort to eradicate tuberculosis …

The success of Mycobacterium tuberculosis (Mtb) is largely attributed to its ability to
physiologically adapt and withstand diverse localized stresses within host …

Abstract For Mycobacterium tuberculosis (Mtb) to successfully infect a host, it must be able to
adapt to changes in its microenvironment, including variations in ionic signals such as pH …

The orphan response regulator PmrA is essential for the intramacrophage growth and
survival of Francisella tularensis. PmrA was thought to promote intramacrophage growth by …

Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin-
resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining …

Paired two-component systems (TCSs), having a sensor kinase (SK) and a cognate
response regulator (RR), enable the human pathogen Mycobacterium tuberculosis to …