Type 2 diabetes mellitus: a review of multi-target drugs

A Artasensi, A Pedretti, G Vistoli, L Fumagalli - Molecules, 2020 - mdpi.com
Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of
population and according to the World Health Organization (WHO) the number of adults …

Functions of interoception: From energy regulation to experience of the self

KS Quigley, S Kanoski, WM Grill, LF Barrett… - Trends in …, 2021 - cell.com
We review recent work on the functions of interoceptive processing, by which the nervous
system anticipates, senses, and integrates signals originating from the body. We focus on …

Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Regulation of postabsorptive and postprandial glucose metabolism by insulin-dependent and insulin-independent mechanisms: an integrative approach

GD Dimitriadis, E Maratou, A Kountouri, M Board… - Nutrients, 2021 - mdpi.com
Glucose levels in blood must be constantly maintained within a tight physiological range to
sustain anabolism. Insulin regulates glucose homeostasis via its effects on glucose …

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

V Frodermann, D Rohde, G Courties, N Severe… - Nature medicine, 2019 - nature.com
A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis;
however, it remains unclear whether regular physical activity influences leukocyte …

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

HK Park, RS Ahima - Metabolism, 2015 - Elsevier
Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Asthma and obesity: two diseases on the rise and bridged by inflammation

M Bantulà, J Roca-Ferrer, E Arismendi… - Journal of clinical …, 2021 - mdpi.com
Asthma and obesity are two epidemics affecting the developed world. The relationship
between obesity and both asthma and severe asthma appears to be weight-dependent …

Drug therapy in obesity: a review of current and emerging treatments

DM Williams, A Nawaz, M Evans - Diabetes Therapy, 2020 - Springer
Whilst the prevalence of obesity continues to increase at an alarming rate worldwide, the
personal and economic burden of obesity-related complications becomes ever more …

Multi-omics microsampling for the profiling of lifestyle-associated changes in health

X Shen, R Kellogg, DJ Panyard, N Bararpour… - Nature Biomedical …, 2024 - nature.com
Current healthcare practices are reactive and use limited physiological and clinical
information, often collected months or years apart. Moreover, the discovery and profiling of …

Flavonoids as antiobesity agents: A review

AT Rufino, VM Costa, F Carvalho… - Medicinal Research …, 2021 - Wiley Online Library
Obesity is a global health problem that affects all age groups in both developing and
developed countries. In recent years, the prevalence of overweight and obesity has reached …