Microglia represent a first-line defense in the brain. However, in pathological conditions
such as Alzheimer's disease (AD), a pro-inflammatory switch may occur, leading to loss of …

Neuronal energy consumption is vital for information processing and memory formation in
synapses. The brain consists of just 2% of the human body's mass, but consumes almost …

Multiple sclerosis (MS) is an incurable chronic neurodegenerative disease where
autoimmunity, oxidative stress, and neuroinflammation collaboration predispose myelin …

Danshen has been widely used for the treatment of central nervous system diseases. We
investigated the effect of dihydroisotanshinone I (DT), a compound extracted from Danshen …

Abstract Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modify the gene
expression through histone deacetylation. SIRT1 plays a crucial role in regulating a wide …

Sirtuins (SIRTs) are described as NAD+-dependent deacetylases, also known as class III
histone deacetylases. So far, seven sirtuin genes (SIRTS 1-7) have been identified and …

Alcoholic liver disease (ALD) poses a significant threat to human health, with excessive
alcohol intake disrupting the immunotolerant environment of the liver and initiating a …

Excessive glutamate neurotransmitters result in oxidative neurotoxicity, similar to
neurodegeneration. An indigenous berry of Thailand, Cleistocalyx nervosum var. paniala …

Stroke is an acute cerebro-vascular disease with high incidence and poor prognosis, most
commonly ischemic in nature. In recent years, increasing attention has been paid to …

Sleep disturbances are an emerging risk factor for metabolic diseases, for which the burden
is particularly worrying worldwide. The importance of sleep for metabolic health is being …