Objective There have been concerns about the long term safety of paclitaxel coated devices
in the lower limbs. A formal systematic review and meta-analysis of randomised controlled …

Objective: The aim of this study was to pool data from randomized controlled trials (RCT)
limited to resectable pancreatic ductal adenocarcinoma (PDAC) to determine whether a …

Background Metabolic–bariatric surgery delivers substantial weight loss and can induce
remission or improvement of obesity-related risks and complications. However, more robust …

Importance Mental stress–induced myocardial ischemia is a recognized phenomenon in
patients with coronary heart disease (CHD), but its clinical significance in the contemporary …

PURPOSE After risk-reducing salpingo-oophorectomy (RRSO), BRCA1/2 pathogenic variant
(PV) carriers have a residual risk to develop peritoneal carcinomatosis (PC). The etiology of …

Importance Conventional meta-analyses with aggregated study-level data have yielded
conflicting results for the comparative effectiveness of tenofovir disoproxil fumarate vs …

Importance Two large randomized clinical trials (RCTs) found that laparoscopic surgery
failed to yield noninferior pathologic outcomes compared with open surgery for patients with …

Prediction models often yield inaccurate predictions for new individuals. Large data sets
from pooled studies or electronic healthcare records may alleviate this with an increased …

Background Chimeric antigen receptor (CAR) T-cell therapies, including axicabtagene
ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel), are innovative treatments for patients with …

Background The optimal oxygenation in mechanically ventilated critically ill patients remains
unclear. Methods We performed a systematic review of randomised controlled trials (RCTs) …