The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …

Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

The mechanisms of malignant cell transformation caused by the oncogenic, chimeric
nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Introduction: Lymphomas are classified based on the normal counterpart, or cell of origin,
from which they arise. Because lymphocytes have physiologic immune functions that vary …

Aberrant forms of the anaplastic lymphoma kinase (ALK) have been implicated in the
pathogenesis of multiple human cancers, where ALK represents a rational therapeutic target …

Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor
superfamily, was initially identified in constitutively activated oncogenic fusion forms–the …

Stromal elements present within the tumor microenvironment may suppress host immunity
and promote the growth of malignant lymphocytes in B cell–derived non-Hodgkin lymphoma …

Myc proteins (c-myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for
progression in cancer. Amplification of the MYCN gene has emerged as one of the clearest …

Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic
features and the consistent expression of CD30. It then became evident that the majority of …