Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis

JJ Wu, A Kavanaugh, MG Lebwohl… - Journal of the …, 2022 - Wiley Online Library
Psoriasis is a chronic systemic inflammatory disorder associated with several comorbidities
in addition to the characteristic skin lesions. Metabolic syndrome (MetS) is the most frequent …

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

MT Patrick, Q Li, R Wasikowski, N Mehta… - Nature …, 2022 - nature.com
Psoriasis and coronary artery disease (CAD) are related comorbidities that are well
established, but whether a genetic basis underlies this is not well studied. We apply trans …

The association between psoriasis and risk of cardiovascular disease: A mendelian randomization analysis

N Gao, M Kong, X Li, X Zhu, D Wei, M Ni… - Frontiers in …, 2022 - frontiersin.org
Background A large number of observational studies showed that patients with psoriasis
have a higher risk of cardiovascular disease (CVD), but most studies did not fully adjust for …

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

Y Han, J Byun, C Zhu, R Sun, JY Roh… - Nature …, 2023 - nature.com
Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly
associated with immune-mediated disorders. In this study, we implemented multitrait joint …

Shared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin‐17 and Janus Kinase–Signal Transducers and Activators of …

MT Patrick, RP Nair, K He, PE Stuart, AC Billi… - Annals of …, 2023 - Wiley Online Library
Objective Psoriasis and multiple sclerosis (MS) are complex immune diseases that are
mediated by T cells and share multiple comorbidities. Previous studies have suggested …

[HTML][HTML] Mendelian randomization studies in psoriasis and psoriatic arthritis: a systematic review

JQ Jin, KG Elhage, RK Spencer, MS Davis… - Journal of Investigative …, 2023 - Elsevier
Psoriasis (PSO) and psoriatic arthritis (PSA) are inflammatory diseases with complex genetic
and environmental contributions. Although studies have identified environmental and …

[HTML][HTML] New frontiers in psoriatic disease research, part II: comorbidities and targeted therapies

D Yan, A Blauvelt, AK Dey, RS Golpanian… - Journal of Investigative …, 2021 - Elsevier
Although psoriasis and psoriatic arthritis (PsA) have been classically considered to be
diseases of the skin and joints, respectively, emerging evidence suggests that a combination …

Site-Specifically launched microneedles for the combined treatment of psoriasis-diabetic comorbidity

X Gao, F Zhang, Y Huang, W Hu, Y Chen… - … Applied Materials & …, 2023 - ACS Publications
Psoriasis and diabetes are both common comorbidities for each other, where inflammation
and insulin resistance act in a vicious cycle, driving the progression of disease through the …

Are periodontitis and psoriasis associated? A pre‐clinical murine model

C Marruganti, C Gaeta, C Falciani… - Journal of Clinical …, 2024 - Wiley Online Library
Aim To investigate the bidirectional influence between periodontitis and psoriasis, using the
respective experimental models of ligature‐and imiquimod‐induced diseases on murine …