Mechanical signalling affects multiple biological processes during development and in adult organisms, including cell fate transitions, cell migration, morphogenesis and immune …
Cells and tissues generate and are exposed to various mechanical forces that act across a range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
B Banushi, SR Joseph, B Lum, JJ Lee… - Nature Reviews …, 2023 - nature.com
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
V Rausch, CG Hansen - Trends in cell biology, 2020 - cell.com
The plasma membrane allows the cell to sense and adapt to changes in the extracellular environment by relaying external inputs via intracellular signaling networks. One central …
AL Le Roux, X Quiroga, N Walani… - … of the Royal …, 2019 - royalsocietypublishing.org
Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is …
In response to different types and intensities of mechanical force, cells modulate their physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …
Emergent physical properties of tissues are not readily understood by reductionist studies of their constituent cells. Here, we show molecular signals controlling cellular, physical, and …
RG Parton, KA McMahon, Y Wu - Current opinion in cell biology, 2020 - Elsevier
Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a platform generated by caveolin integral membrane proteins and membrane lipids. This …
X Wang, Y Shen, M Shang, X Liu… - Cardiovascular …, 2023 - academic.oup.com
Cardiovascular disease (CVD) is a serious health challenge, causing more deaths worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …