Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …

Cells are constantly submitted to external mechanical stresses, which they must withstand
and respond to. By forming a physical boundary between cells and their environment that is …

In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …

Emergent physical properties of tissues are not readily understood by reductionist studies of
their constituent cells. Here, we show molecular signals controlling cellular, physical, and …

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a
platform generated by caveolin integral membrane proteins and membrane lipids. This …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …