Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …

Introduction Long term complications of COVID-19, the disease caused by the SARS-CoV-2,
involve many organ systems, dramatically worsening the quality of life, and finally …

Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …

Testosterone deficiency (TD) is an increasingly common problem with significant health
implications, but its diagnosis and management can be challenging. A multi-disciplinary …

Membrane glycoprotein is the most abundant protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), but its role in coronavirus disease 2019 (COVID-19) has not …

Introduction Despite the ever-increasing occurrences of the coronavirus disease (COVID-19)
cases around the world, very few medications have been validated in the clinical trials to …

Sildenafil is a potent selective, reversible inhibitor of phosphodiesterase type 5 (PDE5)
approved for the treatment of erectile dysfunction and pulmonary arterial hypertension …

Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used
clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and …

Viral infections are a continuing global burden on the human population, underscored by the
ramifications of the COVID-19 pandemic. Current treatment options and supportive therapies …

COVID-19 remains a health care concern despite the end of the pandemic. Patients with
cardiovascular disease (CVD) are at a higher risk for developing severe COVID-19 …